成纤维细胞活化蛋白和成纤维细胞特异性蛋白-1在甲状腺乳头状癌中的表达及临床意义

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Abstract Objective To observe the expression of fibroblast-activated protein (FAP) and fibroblast-specific protein 1 (FSP1) in carcinoma-associated fibroblasts (CAFs) of papillary thyroid carcinoma (PTC),and investigate the correlation between CAFs and PTC.Methods The expression of FAP and FSP1 in PTC,normal thyroid was detected by immunohistochemistry, and the clinicopathologicaI correlation was analyzed.Results FAP and FSP1 didn’t express in normal thyroid,but did in PTC.The positive expressions of FAP and FSP1 were in accord with cancerous fibrous response around PTC cells.In PTC,the expression of FAP was positively related to tumor diameter,lymph node metastasis and TNM staging, but the expression of FSP1 was negatively related to the clinicopathological parameter.Conclusion FAP and FSP1 were the senstive markers of carcinoma-associated fibroblasts(CAFs) in PTC.FAP may be certain significant to predict the malignant biological behavior in PTC.

Key words： papillary thyroid carcinoma carcinoma-associated fibroblasts FAP FSP1

Received: 05 August 2018

PACS:

R736.1

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	Articles by authors
	CAI Li
	HU Jinchen
	JIANG Lei
	QU Guimei
	JIANG Lixin
	ZHENG Haitao

Cite this article:

CAI Li,HU Jinchen,JIANG Lei, et al. Expression and clinical significance of FAP and FSP1 in papillary thyroid carcinoma[J]. 滨州医学院学报, 2018, 41(5): 339-342.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/ OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2018/V41/I5/339

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