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| Study and establishment of thyroid hormones biological reference interval of normal pregnant womenduring different pregnancy periods in Yellow River Delta |
| LIU Jingbo, WANG Lianwen, LI Na, BAI Yu, WANG Shuyun |
| Clinical Laboratory,Binzhou Medical University Hospital,Binzhou 256603,P.R.China |
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Abstract Objective To study the change characteristics of thyroid hormone levels in different pregnant women in the Yellow River Delta, thus to establish a biological reference range of thyroid hormones for normal pregnant women in their early,middle and late stages in the Yellow River Delta.Methods Totally 765 healthy pregnant women were selected in the the Yellow River delta,electro chemiluminescence immunoassay were used to detect their serum TSH,FT3,FT4,TPO-Ab,and TG-Ab, in early, middle and late stages, and at the same time, 188 healthy age-matched non pregnant women were selected as the control group,so as to establish normal reference ranges of thyroid hormones for pregnant women in the Yellow River Delta.Results There were some changes in thyroid hormone levels in pregnant women at different pregnancy stages.The levels of thyroid hormones in pregnant women in different stages showed a partial distribution of thyroid hormones in each stage.The biological reference intervals of thyroid hormone in each stage of pregnancy were indicated by median value (M) and bilateral limit value (P2.5～P97.5).Levels of TSH ,FT3 and FT4 were significantly different between non pregnant women of childbearing age and different stages of pregnant women (P＜0.05 ),which were similar to previous reports from other areas apart from few differences.Conclusion The thyroid hormone levels were different among different stages of pregnant women and normal no pregnant women. It is useful to establish a biological reference range of thyroid hormones for pregnant women in their different stages in the Yellow River Delta, which will help to distinguish thyroid dysfunction in pregnant women and to provide useful assistance for clinical diagnosis and treatment.
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Received: 15 January 2018
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