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| Preparation and quality control of compound spironolactone gel |
| LI Xinxin, BO Mingxiang, WANG Zhenzhen, HU Limin, WANG Yu, FAN Qizhong |
| Department of Pharmacy,Binzhou Medical University Hospital,Binzhou 256603,P.R.China |
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Abstract Objective To prepare compound spironolactone gel and to establish a method for its quality control.Methods The gel was prepared using carbomer-940 as the matrix,and spironolactone and erythromycin as the main ingredients,and the contents of spironolactone and erythromycin was detected by high performance liquid chromatography.Results The gel was exquisite,colorless and transparent,the viscosity was moderate,and the pH value was 7.0~7.5.The linear range was 0.251 6~5.032 μg·mL-1 for spironolactone (r＝0.999 9) and 0.577 2~11.54μg·mL-1 for erythromycin (r＝0.999 9).The average recoveries were 97.80% (RSD＝0.74%,n=9) and 96.7% (RSD＝2.60%,n＝9),respectively.Conclusion The method is simple,and the quality is stable and controllable.
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Received: 05 September 2017
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