急性脑梗死患者联合检测血清脂蛋白相关磷脂酶A2和C反应蛋白水平的临床意义

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Abstract Objective To explore the clinical significance in combined detection of serum Lipoprotein-associated phospholipase A2 (LP-PLA2)and C-reactive protein(CRP) in patients with acute cerebral infarction.Methods Totally 104 patients with acute cerebral infarction were recruited as the experiment group,and 106 subjects were selected as the control group.The levels of serum LP-PLA2 and CRP were measured for the two groups.The difference of serum LP-PLA2 and CRP levels was investigated between stroke patients and control subjects.The carotid artery color-Doppler ultrasonography and brain MRI examination were done for all stroke patients. All the stroke patients were divided into non-plaque group, stable-plaque group and unstable-plaque group according to the findings of carotid artery color-Doppler ultrasonography,and they were also divided into small area infarction group, middle area infarction group and large area infarction group according to the findings of brain MRI.The difference of serum LP-PLA2 and CRP levels was compared among the different groups above.Finally, the correlation analysis between LP-PLA2 and CRP was investigated.Results The levels of serum LP-PLA2 and CRP in stroke patients were significantly higher than those in control subjects (P＜0.01).The levels of serum LP-PLA2 and CRP in stable-plaque group and unstable-plaque group were significantly higher than those in non-plaque group,and in unstable-plaque group they were significantly higher than that in stable-plaque group (P＜0.01).Along with the increase of infarction area, the levels of serum LP-PLA2 and CRP were remarkably increased (P＜0.01). Furthermore,LP-PLA2 was positively correlated with CRP level in stroke patients (r=0.334,P=0.001).Conclusion The combined detection of serum LP-PLA2 and CRP levels was useful to judge the severity of carotid atherosclerosis and infarct area.

Key words： cerebral infarction Lipoprotein-associated phospholipase A2 C-reactive protein

Received: 10 March 2018

PACS:

R743.33

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	Articles by authors
	GUI Qian
	FENG Hongxuan
	WU Guanhui
	CHENG Qingzhang

Cite this article:

GUI Qian,FENG Hongxuan,WU Guanhui, et al. Clinical significance in combined detection of serum Lipoprotein-associated phospholipase A2 and C-reactive protein in patients with acute cerebral infarction[J]. 滨州医学院学报, 2018, 41(3): 180-182.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/ OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2018/V41/I3/180

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