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| Effects of tirofiban on myocardial perfusion and hs-CRP, TNF-,cTnT levels in patients with acute coronary syndrome after Percutaneous coronary intervention |
| CHEN Jingsheng, LI Bo, LONG Weidong |
| Department of Cardiology,Wuchuan People's Hospital,Guangdong,Wuchuan 524500,P.R.China |
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Abstract Objective To investigate the effects of tiroofiban on myocardial perfusion and hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor (TNF- a) and troponin T (cTnT) levels in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods Eighty patients diagnosed as ACS with PCI in our hospital from August 2013 to August 2016 were enrolled in the study and randomly divided into two groups. The control group (n=40) was treated with clopidogrel,aspirin antiplatelet and low molecular weight heparin calcium anticoagulation.The tirofiban group (n=40) was treated with tirofiban on the basis of conventional treatment.The levels of inflammatory factors and thrombosis were observed before and after the treatment.Results After 24 hours of treatment, the patients' levels of hs-CRP,troponin T (cTnT) and TNF-a increased,but the level of tirofiban group was lower (P＜0.05).There was no significant difference between the two groups at 20 min after myocardial perfusion and the incidence of bleeding within 24 h (P＞0.05).The total incidence of thrombosis after tirofiban intervention was lower (P＜0.05).Conclusion Tirofiban can significantly improve the inflammatory response and reduce the risk of thrombosis in patients with ACS,and is worthy of promotion.
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Received: 21 February 2017
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