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| A retrospective study on the clinical efficacy of spironolactone in the treatment of female acne |
| LI Xinxin, FAN Qizhong, BO Mingxiang, HU Limin, WANG Yu, ZHANG Yanmin |
| Department of Pharmacy,Binzhou Medical University Hospital,Binzhou 256603,P.R.China |
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Abstract Objective To retrospectively study the safety and efficacy of spironolactone in the treatment of female acne.Methods The clinical data of a group of women who received spironolactone to treat acne were selected by an electronic medical records search tool to assess the comprehensive acne severity scale before treatment and at each follow-up.The condition of concurrent and previous treatment and adverse reactions were collected at all follow-up.Results The acne symptom of 94 patients in a total of 110 patients improved and 61 completely cured.16 patients had no improvement and 6 patients were recurrent after initial improvement.The acne of face,chest,back had been improved by 73.1%, 75.9%,77.6%, respectively in female patients.51 patients had adverse reactions,6 patients of who discontinued medication.Conclusion Spironolactone has a good effect on the treatment of female acne and has a low recurrence rate.
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Received: 02 January 2018
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[1] Zaenglein A L,Pathy A L,Schlosser B J,et al.Guidelines of care for the management of acne vulgaris[J] .J Am Acad Dermatol,2016,74(5):945-973.
[2] 项蕾红.中国痤疮治疗指南(2014修订版)[J] .临床皮肤科杂志,2015,44(01):52-57.
[3] Shaw J C,White L E.Long-term safety of spironolactone in acne:Results of an 8-year follow up study[J] .J Cutan Med Surg, 2002,6(6):541-545.
[4] Hughes B R,Cunliffe W J.Tolerance of spironolactone[J] .Br J Dermatol,1988,118(5):687-691.
[5] Plovanich M,Weng Q Y,Mostaghimi A.Low usefulness of potassium monitoring among healthy young women taking spironolactone for acne[J] .JAMADermatol,2015,151(9):941-944.
[6] 孙凯亮.杨柳教授有关痤疮学术思想和临床研究[D] .南方医科大学, 2010.
[7] Zaenglein A L,Pathy A L,Schlosser B J.Guidelines of care for the management of acne vulgaris[J] .J Am Acad Dermatol,2016,74(9):945-973.
[8] Stewart D M,Torok H M,Weiss J S,et al.Solodyn Phase 2 Study Group. Dose-ranging efficacy of new once-daily extended-release minocycline for acne vulgaris[J] .Cutis,2006,78(1):11-20.
[9] Barbieri J S,Hoffstad O,Margolis D J.Duration of oral tetracycline-class antibiotic therapy and use of topical retinoids for the treatment of acne among general practitioners (GP):A retrospective cohort study[J] .J Am Acad Dermatol,2016,75(6):1142-1150.
[10] Leyden J,Shalita A,Hordinsky M,et al.Efficacy of a low-dose oral contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel for the treatment of moderate acne: A randomized,placebo-controlled trial[J] .J Am Acad Dermatol,2002,47(3):399-409. |
| [1] |
. [J]. 滨州医学院学报, 2019, 42(2): 144-145. |
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