蛋白质翻译后修饰的质谱鉴定方法和在精准医学研究中的应用

doi:10.19739/j.cnki.issn1001-9510.2021.01.017

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Abstract In recent years, with the development of science and technology, mass spectrometry (MS) has emerged as an innovative analytical technique. MS is suitable for a large number of analyses and is widely used in the field of protein analysis. It has become the main choice for proteomics applications with its efficiency, sensitivity, accuracy, stability and convenience. Proteomics is essential for early stage diagnosis, prognosis and monitoring of disease development. Among them, the protein post-translational modification(PTM) is an important way of regulating protein functionand. The testing of PTM is very important in the experimental process. This article reviews mass spectrometry analysis of PTM(ubiquitination, sumoylation, acetylation, glycosylation)andthe new sumoylation mass spectrometry detection method defined in our laboratory.This article also discusses the application of mass spectrometry in precision medicine.

Key words： protein post-translational modification Mass spectrometry proteomics

Received: 22 September 2020

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R-33

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	ZHOU Yizi
	JIANG Wenguo

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ZHOU Yizi,JIANG Wenguo. Identification of protein post-translational modificationsand application in precision medical research by mass spectrometry[J]. 滨州医学院学报, 2021, 44(1): 76-80.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.01.017 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I1/76

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