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| Constitution and antimicrobial resistance of the pathogens isolated from bloodstream specimens in 2 137 inpatients |
| LI Xia1, JI Bing2, MAN Yuqing3, CHEN Hongna2, WANG Fengxia2* |
1 Department of Obstetrics and Gynecology, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R. China;
2 Department of Clinical laboratory, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R. China;
3 Department of Pharmaceutics, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R. China |
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Abstract Objective To investigate the constitution and analysis of antimicrobial resistance of the pathogens isolated from bloodstream specimens of inpatients in a hospital.Methods Non-repeated specimens of blood culture positive were collected from inpatients with the diagnosis of bloodstream infection from January 2015 to December 2019. Identification and drug susceptibility analysis were adopted by mass spectrometer, API series and Vitek2 Compact. K-B tests and E-tests were used as supplement, and the results were determined according to the CLSI standard 2019. WHONET5.6 software was used for data analysis.Results Totally 2 137 strains of non-repeated pathogens were collected, among which 1312 gram-negative bacteria (61.4%), 776 gram-positive bacteria (36.3%), 29 fungi (1.4%) and 20 anaerobic bacteria (0.9%). The detection rates of CRE in Enterobacteriaceae was 0.3%. And 45.5% ESBLs were detected in Enterobacteriaceae. Strains resistant to vancomycin, teicoplanin and linezolid in Staphylococcus species were not found. The rates of MRSA and MRCNS were 21.7% and 78.5% respectively. One isolate of VRE was detected. The resistance rate of fungi to itraconazole was 10.3% and the resistance rate of anaerobic bacteria to penicillin, tetracycline and clindamycin were 15.0%, 50%, and 70%, respectively.Conclusion Gram-negative bacteria were the main bloodstream infection pathogens in our district, and the drug resistance to the common antibiotics was different and species were diverse. Blood culture should be emphasized by clinics, and do timely and exactly. Antibiotic agents should be selected reasonably according to the results of drug susceptibility tests in clinical treatment.
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Received: 23 May 2020
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