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| Meta-analysis of effectiveness and safety on large-artery atherosclerosis-induced cerebral infarction with combination therapy of argatroban and clopidogrel |
| ZHOU Xiaolong1, ZHANG Ning2, WANG Chunjian1, ZHANG Jinjie1* |
1 Department of Pharmacy, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China;
2 Shandong Academy of Pharmaceutical Sciences, Jinan 250101, Shandong |
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Abstract Objective To systematically analyze the effectiveness and safety on large-artery atherosclerosis-induced cerebral infarction with combination therapy of argatroban and clopidogrel.Methods Literatures about ischemic cerebral infarction with combination therapy of argatroban and clopidogrel were searched in the databases of CNKI, VIP, Wanfang, CBM, Pubmed, Cochrane Library, and Embase from the beginning of the databases to October lst, 2019. Data extraction and quality evaluation were performed after a RCT that met inclusion and exclusion criteria. Meta-analysis was performed by Review Manager 5.3.Results Seven RCTs and 678 subjects were included in our analysis. The results of meta-analysis suggested that the combination therapy group was better than the control group in improving patients' therapeutic efficiency (OR=4.39, P<0.001), NIHSS scores (MD=-1.97, P<0.001), and Barthel scores (MD=7.85, P<0.001). In addition, no significant association was found between two groups in bleeding.Conclusion The current evidence indicates that combination therapy of argatroban and clopidogrel could improve therapy efficiency, neurological impairment and activities of daily living abilities in patients with large-artery atherosclerosis-induced cerebral infarction.
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Received: 11 December 2019
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