NEAT1在胃癌中的表达及与胃癌患者临床病理学参数相关性分析

doi:10.19739/j.cnki.issn1001-9510.2020.03.005

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Abstract Objective To study the clinical significance of LncRNA NEAT1 in gastric cancer.Methods The expression level of LncRNA NEAT1 in gastric cancer tissues and adjacent normal tissues was detected by fluorescence quantitative PCR, and the correlation between the expression level of NEAT1 and the clinicopathological parameters and prognosis of gastric cancer patients was further analyzed.Results The expression of NEAT1 in gastric cancer tissues was higher than that in normal tissues (P<0.01). The expression of NEAT1 was significantly correlated with vascular invasion, distant metastasis, and recurrence in patients with gastric cancer (P<0.05), but not with age, gender, degree of differentiation, nerve invasion, staging, and lymph node metastasis. Univariate and multivariate COX regression analysis showed that the expression level of NEAT1 was related to disease-free survival and overall survival of patients, and could be used as an independent risk factor for the prognosis of gastric cancer patients. Survival analysis showed that gastric cancer patients in the NEAT1 group with high expression had a poor prognosis.Conclusion NEAT1 may play a role in promoting cancer in gastric cancer, and can be used as a potential indicator for clinical diagnosis and prognosis evaluation.

Key words： LncRNA NEAT1 gastric cancer clinical pathology

Received: 10 January 2020

PACS:

R735.2

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	Articles by authors
	ZHANG Jingwei
	YU Xiujuan
	YUAN Yunzi
	GUO Xiuzhen
	DONG Menghua
	HAO Zhihui

Cite this article:

ZHANG Jingwei,YU Xiujuan,YUAN Yunzi, et al. NEAT1 expression in gastric cancer and its correlation with clinicopathological parameters of patients with gastric cancer[J]. 滨州医学院学报, 2020, 43(3): 178-181.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2020.03.005 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2020/V43/I3/178

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