同型半胱氨酸与癫痫关系的研究进展

doi:10.19739/j.cnki.issn1001-9510.2020.02.017

Abstract
Figure/Table
References
Related Citation (2)

Download: PDF (833 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Homocysteine is formed as an intermediate during methionine metabolism. Hcy is known to be an independent risk factor for cardiovascular disease and neurological diseases including epilepsy, stroke, cognitive disorders, Parkinson's disease and Alzheimer's disease. Epilepsy is one of the common diseases of neurology, and it has characteristics of episodic, transient, repetitive and stereotypic. One research has shown that severe hyperhomocysteinemia causes seizures and increases the frequency of seizures. But the interactions between hyperhomocysteinemia and seizures are rare reported in China. This review focuses on the interactions among homocysteinemia, NMDA receptors and epilepsy to further explore the pathogenesis of epilepsy and provides new clinical treatments.

Key words： homocysteine epilepsy N-methyl-D-aspartic acid receptor

Received: 28 June 2019

PACS:

R742.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SHEN Xinyue
	SHI Zhenghao
	HOU Yiwei
	GE Ruli
	WANG Meiling

Cite this article:

SHEN Xinyue,SHI Zhenghao,HOU Yiwei, et al. Research progress on the interactions between homocysteine and epilepsy[J]. 滨州医学院学报, 2020, 43(2): 149-151.

URL:

http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2020.02.017 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2020/V43/I2/149

[1] GANGULY P, ALAM S F. Role of homocysteine in the development of cardiovascular disease[J]. Nutr J, 2015, 14(1):6.
[2] CHEN L, TIAN Q, ZHANG M, et al. CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients[J]. Epilepsy Res, 2019, 154:139-143.
[3] KHAN R, HOSSAIN M A, NAI Q, et al. Hyperhomocysteinemia Association with Transient Global Amnesia: A Rare Case Report[J]. N Am J Med Sci, 2015, 7(8):374-376.
[4] GULATI S. Association of Serum Homocysteine, Vitamin B12 and Folic Acid Levels with Metabolic Syndrome[J]. J Assoc Physicians India, 2018, 66(7):101-102.
[5] MURRAY L K, JADAVJI N M. The role of one-carbon metabolism and homocysteine in Parkinson's disease onset, pathology and mechanisms[J]. Nutr Res Rev, 2019, 32(2):218-230.
[6] VANDER SPEK A, BROER L, DRAISMA HHM, et al. Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium[J]. Sci Rep, 2019, 9(1):11623.
[7] KIM J Y, KO A R, HYUN H W, et al. PDI regulates seizure activity via NMDA receptor redox in rats[J]. Sci Rep, 2017, 7:42491.
[8] HIXSON K M, COGSWELL M, BROOKS-KAYAL A R, et al. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors[J].BMC Genomics, 2019, 20(1):677.
[9] REN X Q, MA R, YANG C Q, et al. Kangxian capsules: Effects on convulsive injuries, N-methyl-d-aspartate (NMDA) receptor subunit expression, and free Ca(2+) concentration in a rat hippoceampal neuron epileptic discharge model[J]. Seizure, 2016, 40:27-32.
[10] COLOMBO M N, FRANCOLINI M. Glutamate at the vertebrate neuromuscular junction: from modulation to neurotransmission[J].Cells, 2019, 8(9):996.
[11] SWANGER S A, CHEN W, WELLS G, et al. Mechanistic insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains[J]. Am J Hum Genet, 2016, 99(6):1261-1280.
[12] JI Y, LYU P, JIN W, et al.Homocysteine: A modifiable culprit of cognitive impairment for us to conquer[J].J Neurol Sci, 2019, 404:128-136.
[13] DEEP S N, MITRA S, RAJAGOPAL S, et al. GluN2A-NMDA receptor-mediated sustained Ca influx leads to homocysteine-induced neuronal cell death[J]. J Biol Chem, 2019, 294(29):11154-11165.
[14] MA T,WU Y,CHEN B, et al. D-Serine contributes to seizure development via ERK signaling[J].Front Neurosci, 2019, 13:254.
[15] KAMAT PK, KALANI A, TYAGI S C, et al. Hydrogen sulfide epigenetically attenuates homocysteine-induced mitochondrial toxicity mediated through NMDA receptor in mouse brain endothelial (bEnd3) Cells[J]. J Cell Physiol, 2015, 230(2):378-394.
[16] YAHATA M, ISHII Y, NAKAGAWA T, et al. Species differences in metabolism of a new antiepileptic drug candidate, DSP-0565 [2-(2'-fluoro[1,1'-biphenyl]-2-yl)acetamide [J]. Biopharm Drug Dispos, 2019, 40(5-6):165-175.