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Diagnostic value of lung ultrasound with high-resolution CT for interstitial lung disease |
YAN Junhong1, GAO Yanbing1, WANG Jing2, CUI Guanghe1, PAN Lei2* |
1 Department of Ultrasonography, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China; 2 Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital |
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Abstract Objective To compare the sensitivity of lung ultrasound (LUS) with high-resolution computed tomography (HRCT) in the diagnosis of interstitial lung disease (ILD). Methods A retrospective analysis of 30 patients with clinically diagnosed ILD who were hospitalized in Binzhou Medical University Hospital from June 2018 to June 2019. All patients underwent bilateral LUS examination and chest high-resolution CT (HRCT) scan with informed consent. The interval between inspection and HRCT is no more than 24 hours.Record the pleural and lung parenchymal sonograms, observe the number of B lines, the thickness of the pleural line, whether the pleural line is regular, whether there is a hypoechoic area under the pleura, and whether there is fluid in the chest. The sensitivity of LUS and HRCT in the diagnosis of ILD was calculated by clinical diagnosis as the gold standard. Results Of the 30 patients with ILD, 4 patients (13.3%) had false negative for LUS and 3 (10%) had false negative for HRCT. No false positive cases were found. All patients were ILD, so the specificity of the examination could not be counted. With the clinical diagnosis of ILD as the gold standard, the sensitivity of LUS and HRCT for the diagnosis of ILD was 0.87 (0.69-0.96) and 0.90 (0.73-0.98), respectively. There was no significant difference in sensitivity between the two groups (P=1.00). Conclusion LUS is not inferior to HRCT in the diagnosis of ILD. Considering its safety, low cost, portability and practicability, LUS can be used as a potential imaging tool to replace HRCT screening ILD.
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Received: 12 July 2019
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[1] RAGHU G, ROCHWERH B, ZHANG Y, et al. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline[J]. Am J Respir Crit Care Med, 2015, 192(2): e3-19. [2] OHNO Y, KOYAMA H, YOSHIKAWA T, et al. State-of-the-Art Imaging of the Lung for Connective Tissue Disease (CTD) [J]. Curr Rheumatol Rep, 2015, 17(12): 69. [3] PICANO E, MATUCCI-Cerinic M. Unnecessary radiation exposure from medical imaging in the rheumatology patient [J]. Rheumatology (Oxford), 2011, 50(9): 1537-1539. [4] GUTIERREZ M, SALAFFI F, CAROTTI M, et al. Utility of a simplified ultrasound assessment to assess interstitial pulmonary fibrosis in connective tissue disorders-preliminary results [J]. Arthritis Res Ther, 2011, 13(4): R134. [5] PINAL-FERNANDEZ I, PALLISA-NUNEZ E, Selva-O'Callaghan A, et al. Pleural irregularity, a new ultrasound sign for the study of interstitial lung disease in systemic sclerosis and antisynthetase syndrome [J]. Clin Exp Rheumatol, 2015, 33(4 Suppl 91): S136-141. [6] WARRICK J H, BHALLE M, SCHABE S I, et al. High resolution computed tomography in early scleroderma lung disease [J]. J Rheumatol, 1991, 18(10): 1520-1528. [7] LICHTENSTEIN D, MEZIERE G, BIDERMAN P, et al. The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome [J]. Am J Respir Crit Care Med, 1997, 156(5): 1640-1646. [8] WILKINS P A, LASCOLA K M. Update on interstitial pneumonia [J]. Vet Clin North Am Equine Pract, 2015, 31(1): 137-157. [9] KAMEDA T, KAMIYAMA N, KOBAYASHI H, et al. Ultrasonic B-Line-Like Artifacts Generated with Simple Experimental Models Provide Clues to Solve Key Issues in B-Lines [J]. Ultrasound Med Biol, 2019, 45(7): 1617-1626. [10] SCHMICKL C N, MENON A A, DHOKARH R, et al. Optimizing B-lines on lung ultrasound: an in-vitro to in-vivo pilot study with clinical implications [J]. J Clin Monit Comput, 2019. [11] WANG Y, GARGAM L, BARSKOVA T, et al. Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review [J]. Arthritis Res Ther, 2017, 19(1): 206. [12] STAUB L J, MAZZALI BISCARO R R, KASZUBOWSKI E, et al. Lung Ultrasound for the Emergency Diagnosis of Pneumonia, Acute Heart Failure, and Exacerbations of Chronic Obstructive Pulmonary Disease/Asthma in Adults: A Systematic Review and Meta-analysis [J]. J Emerg Med, 2019, 56(1): 53-69. [13] SONG G, BAE S C, LEE Y H. Diagnostic accuracy of lung ultrasound for interstitial lung disease in patients with connective tissue diseases: a meta-analysis [J]. Clin Exp Rheumatol, 2016, 34(1): 11-16. |
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