趋化因子CXCL-10与儿童哮喘严重程度相关性分析及机制研究

doi:10.19739/j.cnki.issn1001-9510.2019.04.005

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Abstract Objective To investigate the clinical significance of CXCL-10 and correlation between serum CXCL-10 level and severity of bronchial asthma in children with bronchial asthma. Methods The expression levels of fasting serum CXCL-10, IL-4 and INF-γ in the control group and asthma group were detected by enzyme-linked immunosorbent assay (ELISA) and statistical analysis was performed using Graphpad Prism. Results The serum level of CXCL-10 in children with asthma group was significantly higher than that in the control group (P<0.01). The serum level of CXCL-10 in severe asthma group was significantly higher than that both in the diapause/mild group and the moderate group (P<0.01). The serum level of CXCL-10 is positively correlated with the IL-4 level (P<0.001). Conclusion CXCL-10 is involved in the pathogenesis of bronchial asthma in children by promoting the activation of Th2 lymphocytes.

Key words： bronchial asthma child asthma chemokines CXCL-10 IL-4

Received: 29 March 2019

PACS:

R725.6

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	LI Li
	SUN Yunxiao

Cite this article:

LI Li,SUN Yunxiao. Clinical significance of serum CXCL-10 level and the correlation between severity in children with bronchial asthma[J]. 滨州医学院学报, 2019, 42(4): 253-256.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2019.04.005 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2019/V42/I4/253

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